RESUMO Objetivo: Avaliar o impacto socioeconômico de acidentes motociclísticos de uma metrópole com mais de um milhão de habitantes atendidos, no ano de 2017, em um hospital universitário. Estudar custo e tempo de internação hospitalar das vítimas, avaliar sequelas definitivas e incapacitantes e analisar a inserção no mercado de trabalho seis meses depois do acidente. Métodos: Estudo retrospectivo de 62 pacientes vítimas de acidentes motociclísticos, atendidos na urgência e emergência, levados para procedimento cirúrgico de um hospital universitário. Coleta de dados através do levantamento de prontuários e contato telefônico seis meses após o trauma. Resultados: Lesões relacionadas às vítimas implicaram elevados custos hospitalares. Prejuízo médio por paciente foi de R$ 17.555. Dos que responderam ao questionário do impacto funcional, 64% ficaram afastados da atividade laboral pelo INSS e 84% apresentaram incapacidades físicas parciais ou permanentes após o acidente. Apenas 9 (36%) receberam algum tipo de benefício financeiro do governo. Conclusão: Elevados custos estão diretamente relacionados ao tempo de internação e necessidades cirúrgicas. A maioria das vítimas necessitou de auxílio financeiro e teve sua vida social prejudicada. Investimentos em conscientização dos motociclistas, para que conduzissem respeitando as leis de trânsito e utilizando equipamentos de segurança, e na infraestrutura das rodovias são necessários. Nível de evidência II, Estudo prognóstico.

ABSTRACT Objective: To evaluate the socioeconomic impact of motorcycle accidents of a metropolis with one million inhabitants treated by a university hospital in 2017. To study hospital cost and time of victims, evaluate definite and incapacitating sequelae, and analyze patient’s insertion in the labor market six months after the accident. Methods: Retrospective study of 62 victims of motorcycle accidents treated in the emergency room and referred for surgical procedure in a university hospital. Data were collected from medical records and answers via telephone six months after the trauma. Results: Injuries related to motorcycle accident resulted in high hospital costs. Average loss per patient was R$ 17,555. Of those who answered the functional impact questionnaire, 64% were on paid leave by INSS and 84% presented partial or permanent physical disabilities after the accident. Only 9 people (36%) received any kind of financial benefit from public authorities. Conclusion: High costs are directly related to hospitalization time and surgical needs. Most victims needed financial help and had their social lives aggravated. Investments in motorcyclists’ awareness of traffic laws and use of safety equipment are needed, as well as in road infrastructure. Level of evidence II, Prognostic studies.

RESUMO Objetivo: Avaliar o perfil epidemiológico das vítimas de acidentes motociclísticos ocorridos em uma metrópole com mais de 1 milhão de habitantes atendidas em um hospital universitário de referência no ano de 2017. Métodos: Estudo retrospectivo através da análise de prontuários de 105 vítimas de acidentes motociclísticos ocorridos em Campinas, SP, Brasil, no ano de 2017 atendidas em um hospital universitário de referência que necessitaram de procedimento cirúrgico. Resultados: Oitenta e sete pacientes (82,9%) eram do sexo masculino. Foram verificadas polifraturas em 61 pacientes (58,1%) e politraumatismo em quatorze (13,3%). A fratura de tíbia foi a mais frequente, presente em 65 casos (61,9%). Fraturas expostas ocorreram em 68 pacientes (64,7%). Entre as vítimas de politraumatismo, a lesão mais recorrente foi o traumatismo cranioencefálico (TCE), presente em sete pacientes (6,6%). A média de idade foi 29,8 anos (variando de 6-63 anos). O tempo de internação médio foi 14 dias (1-87). Conclusão: É fundamental investigar e avaliar o perfil epidemiológico das vítimas, assim como os agravos resultantes, de modo a propiciar subsídio adequado para implementação de medidas de prevenção primária e conscientização, especialmente direcionadas para os grupos mais acometidos. Nível de Evidência II, Estudos prognósticos - Investigação do efeito de característica de um paciente sobre o desfecho da doença.

ABSTRACT Objective: To evaluate the epidemiological profile of motorcycle accident victims in a metropolis with more than one million inhabitants attended in a university hospital of reference in 2017. Methods: a retrospective study through the analysis of medical records of 105 motorcycle accident victims in Campinas (SP) attended in a university hospital of reference and who needed surgical procedure in 2017. Results: 87 patients (82.9%) were men. Multiple fractures were observed in 61 patients (58.1%) and polytrauma was found in 14 patients (13.3%). Tibial fracture was the most frequent, present in 65 cases (61.9%). Exposed fractures occurred in 68 patients (64.7%). Among the polytrauma victims, the most frequent injury was traumatic brain injury (TBI), present in seven patients (6.6%). The mean age was 29.8 years (range 6-63 years). The average length of hospital stay was 14 days (1-87). Conclusion: It is essential to investigate and evaluate the victims’ epidemiological profile, as well as the resulting injuries, in order to provide adequate support for the implementation of measures aimed at primary prevention and awareness of the most affected groups. Level of Evidence II, Prognostic studies - Investigating the effect of a patient characteristic on the outcome of disease.

OBJECTIVES: The aim of this study was to evaluate the quantitative serum level of infliximab (IFX) as well as the detection of anti-infliximab antibodies (ATIs) in patients with Crohn’s disease (CD). METHOD: Forty patients with CD under treatment at a tertiary center in southeastern Brazil were evaluated. Their use of infliximab was continuous and regular. We analyzed and compared the differences in the IFX and ATI levels between the patients with active CD (CDA) and those with CD in remission (CDR). RESULTS: There was no difference in the IFX level between the CDA and CDR groups (p>0.05). Eighty percent of all patients had IFX levels above the therapeutic concentration (6-10 μg/mL). Two (9%) of the 22 patients with active disease and four (22.2%) of the 18 patients in remission had undetectable levels of IFX. Four (66.6%) of the six patients with undetectable levels of IFX had positive ATI levels; three of these patients were in remission, and one had active disease. In addition, the other two patients with undetectable levels of IFX presented ATI levels close to positivity (2.7 and 2.8 AU/ml). None of the patients with therapeutic or supratherapeutic IFX levels had positive ATI levels. CONCLUSIONS: The undetectable levels of IFX correlated with the detection of ATIs, which was independent of disease activity. Immunogenicity was not the main factor for the loss of response to IFX in our study, and the majority of patients in both groups (CDA and CDR) had supratherapeutic levels of IFX.